Jeremiah’s mountain Cream

CBD Arthritis Cream

Jeremiah’s Mountain Cream contains 567 mg per ounce of the additive Cannabidiol (CBD) and has been able to penetrate the skin effectively because of the therapeutic nature of natural plant oils working together on the skin to pull the organic CBD molecule into the skin to address inflammation induced pain. 

$59.98

Ingredients:

Distilled Water, Castor oil, Black cumin seed oil, Tamanu oil, Coconut oil, Shea butter, Evening primrose oil, Grape seed oil, Chia seed oil, Hemp oil, Japonica Camillia oil, Tamanu butter, Sunflower oil, Cetyl alcohol, Steric acid, Xanthan gum, Cannabidiol (CBD), Safflower based phosphatidylcholine, Ethanol, (Germal plus preservative).

JEREMIAH’S MOUNTAIN CREAM

$59.98

INGREDIENTS:

Distilled Water, Castor oil, Black cumin seed oil, Tamanu oil, Coconut oil, Shea butter, Evening primrose oil, Grape seed oil, Chia seed oil, Hemp oil, Japonica Camillia oil, Tamanu butter, Sunflower oil, Cetyl alcohol, Steric acid, Xanthan gum, Cannabidiol (CBD), Safflower based phosphatidylcholine, Ethanol, (Germal plus preservative).

Additional information

Weight 2.35 oz
Dimensions 1.75 × 1.75 × 1.75 in

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Product Details

The mechanism of action of CBD is as follows and can be verified by the references from which this information has been sourced. The sources are from scientific periodicals that have been peer-reviewed through the credible scientific community.

Background into certain types of Pain on a Molecular Level
The chemistry that takes place within the human body is very complex on the biomolecular level, however with the completion of the human genome sequencing project, many bio-compounds and systems have been understood and functions identified.

Of these a group of transmembrane proteins comprising the superfamily of G protein-coupled receptors (GPCRs), that share a common seven-transmembrane configuration with each participating in a diverse physiological and pathological set of functions.

A transmembrane protein is permanently attached to a membrane for example to a cell wall, which is actually a membrane and spans across the cell membrane to the inner cavity of the cell. The transmembrane protein function to transport specific signals or substances in and out of the cell wall via the receptors, which bind to a broad range of ligands, including other types of proteins1, peptides2, organic compounds3,4, and eicosanoids5. GPCRs and their signal transduction pathways as they are referred to, function to induce a variety of physiological and therapeutic approaches ranging from control of blood pressure, allergic responses, hormonal disorders and pain sensations to name a few. GPCRs are important to understand their function and treat physiological problems and thus far 36% of the drugs currently on the market came from understanding the G protein-coupled receptors6.

Of these receptors, a specific one has been identified that involves signaling entities that cause pain and releases cytokines that cause inflammation, which of course perpetuates that pain. This protein receptor is called GPR55 and is a cannabinoid receptor7.

In 2008, Penny Staton of King’s College London8 showed that by removing the GPR55 receptor in certain mice, the inflammation and neuropathic pain associated with surgically damaging the sciatic nerve, and chemically induced inflammation protocols, which normally produce hyperalgesia, which is abnormally heightened sensitivity to pain; was not observed and furthermore, the associated cytokines released in such stimulus was not present. Mice with the GPR55 receptor released all the associated cytokine genes that induce inflammation and tell the brain that there is a lot of pain is present in the affected area and of course produce oxidation via free radical compounds all of which were identified and measured and reported in her paper.

Cannabidiol CBD as an anti-inflammatory via inhibition of GPR55
Cannabidiol or CBD as it is commonly called is a non-psychoactive component of cannabis. It is an antagonist of the GPR55 receptor, meaning it binds or inhibits GPR55 thereby inactivating it’s pronociceptive signaling or rather cutting off communication to genes that releases pain and inflammation signaling as demonstrated by Malfait9, Costa10 and Ryberg11 and as exemplified by the Penny Staton paper discussed above.

The types of genes involved in signaling and production of inflammation and pain are: Cytokines IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12, TNFα, IFNˠ, and GM-CSF.

Transient Receptor Channels TRP, are ion channels located on plasma membranes of mammalian cell types that function as sensors for a wide spectrum of physical and chemical stimuli. They are involved in the formation of sight, hearing, smell, taste, temperature and pain sensation. CBD has been shown to bind or inhibit the action of these sensors with regard to pain signaling as demonstrated by Fioravanti12, and Kress13.

The TRP channels are divided into seven subfamilies. The group I subset TRPV, specifically TRPA1 and TRPV1 where investigated as two widely activated ion channels found in peptidergic nociceptors, which are a type of receptor that sends signal to the brain and spinal cord informing on damaging or potentially harmful stimulus.

It was shown by Davis14, Szabo15, Petrus16, Kerstein17, and Akopian18, that TRPA1 and TRPV1 where inhibited by CBD, which put a stop to inflammation, swelling formation, and inflammation-induced mechanical & thermal hypersensitivity.

After inflammation formation, TRPV1 is detected in synovicytes, cells located in the lining membrane of joint capsules and secrete lubricating fluid into the synovial space and function as local immune cells19. When TRPV1 activates the synoviocytes, they release the cytokines such as IL-1α, IL-6, TNFαand RANTES plus COX-2 in the spine20-22.

The release of TNFα creates a cycle of perpetual inflammation induced pain by further causing the production of TRPV1 in synovocytes19. The progression of this cycle was inhibited by the application of CBD as demonstrated by Malfait9 and Kochukov19.

Thus, the mode of action of CBD involves binding or inhibition of the CPR55 receptor thereby stopping the receptor action to produce pain causing reactions and signaling through a molecular process outlined by Staton et al. As CBD isa natural product extracted from plant material, it has no reported adverse side affects as do most natural supplement type components.

What Customers Are Saying

“The difference in these two pictures are just 5 days apart. My mother had skin cancer removed. The first is right after she got out her stitches and the second was today.”

“Two pictures of my left hand taken on Aug. 9th shows swelling at base of my thumb from arthritis in the joint. It was so painful I wanted to cry. Started Jeremiah’s cream and it helped the pain immensely… last picture shows it today, swelling and pain almost gone!”

Marianne I.

“I want to thank you for suggesting the Jeremiah’s Mountain Cream to help me with my arthritis and knee pains.

I took it on my trip to my NYC trip last month and boy, did it come in handy. All that walking really affected my knees. I put it on in the evenings when we got back from all that sight seeing because I was seriously hurting. What a relief!! In the morning I was ready to go. After two days of applying it before bedtime, I decided to apply it in the morning, also. Oh, that was a smart move! I could walk over 10,000 steps and feel great! No aches!

Another thing I especially like about this cream is that it is smooth and non greasy!

Earlier this summer I bought a small jar of CBD cream-Nature’s Love, organic topical ReLeaf Salve-at a mall in NC (that I still have). It was waxy feeling and had a peculiar scent to it. I read the ingredients- organic virgin coconut oil, organic beeswax, organic proprietary Cultivars Hemp Extract, Organic essential oils. Beeswax!!! That explains the stickiness. I don’t care for the texture or the scent. I prefer the smooth JMC and the faint scent dissipates.

I decided to test it out by putting the NC beeswax based cream on my right knee and the TN cream on the left to see which one was better. I thought it would be even Steven But NO! I felt the difference. The Jeremiah Mountain cream from TN won – pain relief, not sticky and the faint scent had dissipated.

One of the ladies on the trip was complaining about her leg pains in her calf that was aggravated by so much walking and climbing steps. I offered my little sample to her and shared my success with it. Her husband was skeptical about it when I said it was a CBD cream. I told him it was legal, safe and I was using it and that I bought it from a reputable store in Sieverville, TN.

Kathy loved it!! She saw a big difference in her “no pain” leg. She said she uses bio freeze normally but the Jerimiah Mountain cream was more effective. It took care of the pain and she couldn’t believe how much better the results were than her bio freeze. She used it the whole trip and found daily relief.

When we got back home she asked me where she could buy some more. I told her I was putting in an order and I would order her a jar.
We have put in an order to receive more of the Jerimiah Mountain cream and can’t wait to receive it.

Kathy said next time her husband complains about his shoulder after golfing she will offer to put some on it. I can’t wait to hear what he has to say about it. I’m confidant that he’ll feel the relief and then he’ll be asking for his own jar.

I am so pleased with the BIG Results from the Small jar of Relief.

Thanks, again, Marcus. I would have never tried Jeremiahs cream thinking all CBD creams are the same. Now I know. There is a difference! You have to try it to believe it.
I believe in your product!!!”

Sincerely,
Janet D. Van Horn

JEREMIAH’S MOUNTAIN CREAM

$59.98

INGREDIENTS:

Distilled Water, Castor oil, Black cumin seed oil, Tamanu oil, Coconut oil, Shea butter, Evening primrose oil, Grape seed oil, Chia seed oil, Hemp oil, Japonica Camillia oil, Tamanu butter, Sunflower oil, Cetyl alcohol, Steric acid, Xanthan gum, Cannabidiol (CBD), Safflower based phosphatidylcholine, Ethanol, (Germal plus preservative).

Additional information

Weight 2.35 oz
Dimensions 1.75 × 1.75 × 1.75 in

Reviews

There are no reviews yet.

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References

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